IM/IV/SC 10,000-20,000 IU/m2 wkly or twice wkly. Alternatively, 15,000 IU daily for 7 days followed by 3 wk off-treatment & repeat twice so total dose: Approx 300,000 IU is administered. Intra-arterial 30,000-60,000 IU once or twice wkly until total recommended dose: 300,000 IU is reached. Repeat treatment: 150,000 IU may be commenced after min 3-4 wk following completion of 1st course.
Hypersensitivity. Patients w/ acute pulmonary infection or greatly reduced lung function. Repeat course of therapy in patients who have shown any signs of pneumonitis or decreased pulmonary function.
Anaphylaxis. Discontinue use if pulmonary changes are noted & if forced vital capacity decreases rapidly. Pneumonitis; lung cancer; compromised pulmonary function; smoking, lymphoma. Perform baseline & subsequent mthly evaluation of carbon monoxide diffusion capacity & wkly chest X-rays up to 4 wk after treatment completion. Cumulative total dose >400,000 IU. Concomitant use w/ anaesth, cisplatin, granulocyte colony stimulating factor; administration as combination therapy. Previous cytotoxic drug therapy or radiation therapy (especially chest irradiation). Hepatic & severe renal impairment. Pregnancy. Not to be used during lactation. Patients >70 yr.
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